PhD Position in Soft-Matter Modeling for Mechanobiology

Job description

A 4-year PhD position is available at the interface of biophysical modeling, soft matter and cell mechanobiology at the Groningen Research Institute of Pharmacy, within the Faculty of Science and Engineering at the University of Groningen.

What are you going to do?

The project addresses a central question in mechanobiology: how do cells sense, encode and respond to mechanical cues? You will develop a quantitative and predictive framework that links the generation and transmission of mechanical forces to cell mechanics and intracellular signalling, with particular emphasis on mechanosensitive calcium signalling. The aim is to determine how the magnitude, spatial distribution and temporal dynamics of mechanical cues shape cellular responses.

You will investigate an integrated cell–material system in which living cells are mechanically coupled to a stimuli-responsive soft material. Controlled external stimulation will deform the material and generate spatially and temporally defined forces at the cell–material interface. You will develop analytical and numerical models that predict material deformation, force transmission to cells and the resulting changes in cellular mechanics and signalling. The position is primarily computational, but a successful candidate will also contribute to experiments.

Requirements

We are looking for a curious candidate who enjoys working at the interface of physics, engineering and biology, and who meets the following qualifications:

Essential qualifications

·      M.Sc. degree in Applied Mathematics, Biophysics, Mechanical Engineering, Materials Science or related disciplines

·      A strong foundation in continuum mechanics and transport phenomena

·      Experience with numerical methods and finite-element modeling using COMSOL

·      An interest in biological systems and in connecting theoretical models with experimental observations

·      Enthusiasm, self-motivation, creativity, and team spirit

·      Excellent communication skills in English (verbal and written)

Preferred qualifications

·      Experience with fluorescence or live-cell imaging

·      Hands-on experience with microfabrication and microfluidics  

·      Familiarity with cell culture and biological assays

Employer

At the University of Groningen (UG), researchers from all fields of academia and technology are working on academic challenges and societal questions. Lecturers prepare their students for meaningful careers within or outside the academic world. Interdisciplinary research and teaching, sharing of knowledge, collaboration with businesses, government institutions, and societal organizations are aspects that are of the utmost importance to this European top university. The UG aims to be an open academic community with an inclusive and safe working climate that invites you to add your value.

Additional information

Do you have any questions or need more information?

Questions about the content of the job?
Vesna Bacheva (Assistant Professor): v.bacheva@rug.nl

Questions about your application process?
Vesna Bacheva (Assistant Professor): v.bacheva@rug.nl