PhD position in Dermatology

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Description of the workplaceThe doctoral project will be carried out in the field of peptidomics. The research group operates at the Biomedical Center (BMC) at the Department of Dermatology and Venereology at IKVL, Lund University and conducts translational research on how congenital defense mechanisms regulate infection, inflammation and fabric A special focus is on proteolytic released, endogenous peptides and their importance in wound healing and on the development of new peptide-based treatment concepts. The research group is led by Professor Artur Schmidtchen.

The group consists of about seven people, including senior researchers, doctoral students and research staff, with complementary expertise in clinical and translational dermatology, microbiology, immunology, molecular biology and biochemistry. The work is conducted in close collaboration with clinical activities and with biomas and experts in proteomics, peptidomics and bioinformatics at Lund University.

The Department of Clinical Sciences Lund is now a postgraduate education site and employment as a doctoral student in the postgraduate education element Medical science - Dermatology in the doctoral project "Peptidomics of wound fluid guides the discovery The business is located at the Faculty of Medicine, Lund University, and is conducted in an international and interdisciplinary environment.

We are offeringLund University is a state authority, which means that you get special benefits, generous holiday and a favorable occupational pension. We also have a flex-time agreement that creates good conditions for the balance between work and leisure. Read more on the university's website about being employed at Lund University work with us.

Tasks and responsibilitiesThe doctoral student will conduct a defined postgraduate project with a focus on identifying and characterizing bioactive endogenous peptides in infection, inflammation and wound healing. The project is a central part of the group's ongoing research and is carried out in collaboration with biomas and experts in proteomics and peptidomics at Lund University. The tasks include planning and implementing experiments, development and optimization of test preparation methods, peptide enrichment and fractionation and analysis with LC-MS / MS based on DDA and DIA methodology.

The work also includes bioinformatic and statistical analysis of peptidom data to identify peptide patterns, proteolytic signatures and candidate peptides with possible significance for infection, inflammation and wound healing. Selected peptides should be characterized in microbiological and cell-based assays, both individually and in combination, for antimicrobial and immunomodulatory effects.

The doctoral student is responsible for documentation, quality assurance and compilation of the results and to present and publish the research in scientific contexts. The employment also includes participation in the research group's seminars, collaborations and other scientific activities and the implementation of courses and other parts within postgraduate education.

QualificationsFor the employment is required

• Master of Science in Biotechnology, with a focus on medicines or molecular biotechnology.
• Documented experience of basal biochemistry, including SDS-PAGE, LC-MS / MS mass spectrometry (DDA and DIA), and managing human samples.
• Knowledge and experience in peptide biology and peptidomics, including the assay of complex data sets using specialized peptidomikverktyg.
• Experience of MS data analysis with tools such as Fragpipe and Dia-Nn, as well as basic programming skills in Python.
• Practical experience of antibacterial analyzes based on dilution or diffusion methods.
• Very good knowledge of Swedish and English, both in speech and writing.
• Good cooperation ability and a high degree of accuracy and responsibility.

 Merit is

• Previous experience of work with mass spectometric analyzes.
• Experience of project work in international or multicultural environments.
• Experience of method development and troubleshooting experiments.
• Experience of combinatorial analyzes of antimicrobial peptides.

Basic eligibility

Basic eligibility for postgraduate education is required, which means: degree at advanced level, or completed course requirements for at least 240 High school credits, at least 60 High school credits at advanced level, or otherwise acquired corresponding knowledge.

CriteriaProvisions for employment as a doctoral student can be found in Regulation SFS 1998: 80. As a holder, only the person who is adopted to postgraduate education is accepted.

In the case of selection among eligible applicants, particular attention will be attached to:

• Scientific maturity and analytical ability
• Motivation, Independence and Cooperation Skills
• Ability to assimilate postgraduate education
• How the applicant's background and experience is expected to contribute to the project's implementation. 

Terms and conditionsThe employment is a time-limited employment as a doctoral student for full-time for four years (48 months), in accordance with HF 5 Cape 7 §. Access is planned for 1 December 2026 or as agreed.

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