Associate researcher in experimental cardiovascular research

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Description of the workplace

The employment is located in a research group with a focus on cardiovascular and neurovascular disease, with particular interest in mechanisms that connect vascular dysfunction and sphingolipid signaling to organ damage. The group conducts translational research with experimental disease models and combines functional phenotyping with cellular, histological and molecular methods.

The assistant researcher will contribute to the group's work in experimental cardiovascular research with a focus on heart attack and heart failure and Sfingolipidrelated mechanisms. The work is conducted in an international research environment and includes cooperation with other research groups and infrastructures at Lund University.

We are offering

Lund University is a state authority, which means that you get special benefits, generous holiday and a favorable occupational pension.

We offer an international and interdisciplinary research environment with access to established experimental models and advanced methods for cardiovascular phenotyping, cellular and molecular analysis and image analysis. The work provides the opportunity to combine several methodological approach to studying mechanisms behind cardiovascular disease.

Read more on the university's website about being employed with us working with us.

Tasks and responsibilities

You will work with experimental research on mechanisms that contribute to development and progression of cardiovascular disease, with a particular focus on heart attack, subsequent cardiac dysfunction and neurocardiovascular regulation.

Your main tasks will be to:

• Implement and analyze experimental heart attack models in rodents, including surgical ligation of the left front downward coronary artery (LAD ligation),
• Implement and analyze cardiac milling for functional and structural characterization of the heart, analyze sympathetic and vagal nerve innovation and nerve paths related to the cardiovascular function,
• Conducting tissue clearance and light-sheet microscopy for three-dimensional visualization and quantitative analysis of nerve and vascular structures,
• Carry out histological, immunohistochemical and molecular analyzes of heart and nerve tissue,
• Analyze and interpret data for sphingolipid metabolism and S1P signaling.
• Integrate functional, cellular, histological and molecular data and implement statistical analysis,
• Document and compile research results and contribute to scientific publications and presentations,
• Collaborate with other members of the research group and external partners.

Qualifications

Requirements for the employment are:

• PhD in biomedicine, medicine, physiology or other for the employment relevant area,
• Documented research experience in experimental cardiovascular research.
• Practical experience of experimental models for heart attack and / or heart failure in rodents.
• Experience of functional phenotyping of the heart, including cardiovascular MR,
• Experience of histological and molecular biology analyzes of cardiovascular tissue.
• Good ability to independently plan, implement, analyze and document experimental research work,
• Good ability to communicate scientific results in English in speech and writing,
• Good cooperation capacity in an interdisciplinary and international research environment.

Merit for the employment is:

• Experience of Tissue Clearing and Light-Sheet Microscopy,
• Experience of analysis and visualization of sympathetic and vagal nerve innervation and nerve paths,
• Experience of three-dimensional image analysis and quantitative analysis of microscopic image data,
• Experience of research on sphingolipids, especially S1P signaling, in relation to cardiovascular disease,
• Experience of analysis of mass spectrometric generated lipid data,
• Experience of combining neurobiological, immunological and cardiovascular analyzes.

Other

The employment is a special fixed-term employment (fitting) under 12 months with scope 80 percent. Desired Start Date is 2026-11-01 or by appointment.

This is how you are looking for

The employment is searched via Lund University's recruitment system. The application must contain personal letter with justification for the interest in the employment and a description of how the applicant's experience corresponds to the tasks and qualification requirements. The application must also include CV, publication list, diplomas for doctoral degree and contact information for reference persons.

More information about the Faculty of Medicine

The Faculty of Medicine is an area of activity within Lund University, with responsibility for education and research in medicine, health and health. The education takes place in close collaboration with health care and is well anchored in the faculty's strong research tradition. The faculty's research spans a wide field in experimental basic research, patient-related clinical research and health science research. The medical faculty, with just over 1800 employees and 3000 students in Lund, Malmö and Helsingborg, is a knowledge-intensive meeting place for students, teachers and researchers from around the world.

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