Two Postdoc Positions on Synthetic Cells

Job description

Contribute to breakthrough research on synthetic cells chemistry of the future. We are looking for two postdoctoral researchers to develop synthetic cells that can produce valuable products from waste streams.
These positions are part of a European consortium Propel, which aims to revolutionise sustainable bio-manufacturing through the creation of the first integrated, cost-efficient and scalable pipeline for the production of protein-based materials and biocatalysts using synthetic cells.
A key objective is the bottom-up construction of synthetic cells that are capable of sustained protein production. This is a formidable challenge as we lack a blueprint that allows for a bottom-up engineering approach. At the same time, there is an experimental bottleneck: the number of ingredients (lipids, amino acids, cell-free gene expression machinery) prevents a trial-and-error approach where the complete experimental space can be explored such that a large number of experiments will include the correct solution to the problem.
You will develop a design-build-test-learn cycle, combining high throughput experiments and active learning to obtain synthetic cells with the desired properties. You will integrate liquid handling robots and high-speed microscopy with AI and machine learning to form stable liposomes from libraries of (novel) phospholipids that can robustly encapsulate cell-free gene expression systems. You will then expand this pipeline to optimise the yield and especially the robustness of the cell-free expression system. The result will be synthetic cells that can be used across the consortium to degrade plastic waste and transform waste products into valuable biomaterials.

Requirements

• You have a PhD degree in synthetic biology, chemical engineering or a related discipline.
• You have practical experience with cell-free gene expression systems and/or liposomes.
• You take an interest in liquid handling robots, Python and Bayesian optimisation.
• You are a team player and enjoy working in a multidisciplinary environment.
• You have a strong publication track record.
• You have a good command of spoken and written English.

Employer

Faculty of Science
The Faculty of Science (FNWI), part of Radboud University, engages in groundbreaking research and excellent education. In doing so, we push the boundaries of scientific knowledge and pass that knowledge on to the next generation.
We seek solutions to major societal challenges, such as cybercrime and climate change and work on major scientific challenges, such as those in the quantum world. At the same time, we prepare our students for careers both within and outside the scientific field.
Currently, more than 1,300 colleagues contribute to research and education, some as researchers and lecturers, others as technical and administrative support officers. The faculty has a strong international character with staff from more than 70 countries. Together, we work in an informal, accessible and welcoming environment, with attention and space for personal and professional development for all.
Radboud University
At Radboud University, we aim to make an impact through our work. We achieve this by conducting groundbreaking research, providing high-quality education, offering excellent support, and fostering collaborations within and outside the university. In doing so, we contribute indispensably to a healthy, free world with equal opportunities for all. To accomplish this, we need even more colleagues who, based on their expertise, are willing to search for answers. We advocate for an inclusive community and welcome employees with diverse backgrounds, cultures, and perspectives.
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Additional information

You can apply only via the button below. Address your letter of application to Prof. Wilhelm Huck. In the application form, you will find which documents you need to include with your application. We look forward to receiving your application.
Applications will be reviewed, and interviews scheduled during the recruitment period. Therefore, you will receive feedback and information about a possible follow-up process shortly. If a suitable candidate is found before the closing date, the vacancy will be closed, and further applications will no longer be possible. The interview slots will be scheduled in consultation with the shortlisted applicants. You will preferably start your employment on 1 November 2026.
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